Figure 1: Genome-wide association results for traits with genomewide significant hits in the meta-analysis of GWAS and replication phases. | Nature Communications

Figure 1: Genome-wide association results for traits with genomewide significant hits in the meta-analysis of GWAS and replication phases.

From: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Figure 1

Manhattan plots for a. PCOS, b. LH levels. Alternating blue and red colours indicate genotyped SNPs, and accompanying black and grey colours indicate imputed variants, on odd and even chromosomes, respectively. The red horizontal red line indicates genomewide significance. QQ plots and λGC/ λGC1000 are inset in the upper right corner of each plot. For (a) PCOS, P values are from sample-size weighted two-strata meta-analysis of strata-specific logistic regression P values (Stage 1: 984 cases and 2,964 population control women; Stage 2: 1,799 PCOS cases and 1,231 phenotyped reproductively normal control women). For (b) LH levels, P values are from sample-size weighted two-strata meta-analysis of strata-specific linear regression P values (Stage 1: 645 PCOS cases; Stage 2: 399 PCOS cases).

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