Figure 3: ENCODE histone mark profile for genomewide significant PCOS and LH level GWAS loci (http://www.roadmapepigenomics.org/data). | Nature Communications

Figure 3: ENCODE histone mark profile for genomewide significant PCOS and LH level GWAS loci (http://www.roadmapepigenomics.org/data).

From: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Figure 3

Methylation marks in four PCOS relevant human tissue mapping to: (a) Chr. 9 PCOS locus (c9orf3/FANCC), (b) Chr. 11 PCOS and LH level locus (FSHB/ARL14EP) and (c) Chr. 8 PCOS locus (GATA4/NEIL2). Each is a schematic of the genomic region including diagrams of genes mapping to the region. ChipSeq signal tracks for each tissue (AN, adipose nuclei; AL, adult liver; PI, pancreatic islets; SM, skeletal muscle) for six histone marks (H3K27m3, H3K36m3, H3K4m1, H3K4m3, H3K9ac and H3K9m3) are labelled to the left of the panel.

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