Table 1 Demographic characteristics of PCOS cases and controls in the GWAS and replication.

From: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Cohort

GWAS

Replication

 

Age (years)

BMI (kg m−2)

Testosterone (ng dl−1)

Age (years)

BMI (kg m−2)

Testosterone (ng dl−1)

 

Case

Control

Case

Control

Case

Control

Case

Control

Case

Control

Case

Controls

PCOS Family Study*

28 (24–32)

n=718

—

35.5 (29.1–41.4)

n=718

—

72 (59–91)

n=663

—

28 (24–32)

n=172

29 (24–33)

n=105

35.0 (28.3–41.5)

n=172

30.7 (23.3–35.0)

n=105

70 (59–93)

n=100

28 (17–35)

n=35

     

63 (44–77)

n=30

—

    

68 (49–86)

n=47

25 (19–32)

n=70

PPCOSI*

28 (26–30)

n=64

—

35.3 (27.4–42.1)

n=64

—

60 (44–82)

n=62

—

—

—

—

—

—

—

University of Chicago†

29 (25–34)

n=202

—

36.2 (31.8–42.1)

n=202

—

68 (52–93)

n=202

—

27 (23–30)

n=25

—

38.4 (32.4–42.7)

n=25

—

64 (50–85)

n=25

—

NUgene

—

46 (34–58)

n=2,964

—

25.0 (22.0–29.8)

n=2,964

—

—

—

—

—

—

—

—

Cedars–Sinai Medical Center‡

—

—

—

—

—

—

26 (22–31)

n=130

37 (27–42)

n=17

27.7 (22.5–33.9)

n=130

24.6 (21.5–31.5)

n=17

43 (31–62)

n=121

23 (17–29)

n=11

Massachusetts General Hospital

—

—

—

—

—

—

28 (24–32)

n=472

25 (22–31)

n=402

29.0 (23.9–37.0)

n=472

23.0 (21.1–25.0)

n=402

—

—

Medical College of Wisconsin*

—

—

—

—

—

—

—

38 (32–41)

n=452

—

31.9 (24.2–38.9)

n=452

—

19 (15–24)

n=452

PPCOSII*

—

—

—

—

—

—

28 (26–31)

n=265

—

35.1 (26.6–41.8)

n=265

—

50 (37–67)

n=265

—

University of Alabama at Birmingham§

—

—

—

—

—

—

27 (22–33)

n=193

32 (26–36)

n=91

34.1 (27.8–40.8)

n=193

23.7 (21.7–27.7)

n=91

77 (63–94)

n=193

44 (32–56)

n=81

University of Athens||

—

—

—

—

—

—

23 (20–28)

n=542

26 (23–34)

n=164

24.5 (21.4–30.9)

n=542

22.0 (20.1–24.5)

n=164

72 (61–89)

n=542

31 (25–43)

n=163

Imperial College London/University of Oxford¶

—

—

—

—

—

—

32 (28–36)

n=222

45 (45–45)

n=1,335

28.4 (23.2–36.5)

n=217

25.5 (23.0–29.4)

n=1,335

69 (53–86)

n=223

—

  1. PCOS, polycystic ovary syndrome; BMI, body mass index; GWAS, genome-wide association studies. Data are expressed as median (25th–75th interquartile range). Hormone results are separated by assay method when multiple methods and labs were used within a cohort, however the normal range was identical.
  2. *Testosterone normal range<59 ng dl−1
  3. †Testosterone normal range<71 ng dl−1.
  4. ‡Testosterone normal range<35 ng dl−1.
  5. §Testosterone normal range<85 ng dl−1.
  6. ||Testosterone normal range<60 ng dl−1.
  7. ¶Testosterone normal range<70 ng dl−1
Back to article page