Figure 7: Evidence of SIRT1 misregulation in vivo. | Nature Communications

Figure 7: Evidence of SIRT1 misregulation in vivo.

From: Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence

Figure 7

(a) Images of IHC staining and quantification of SIRT1 levels in epithelial cells from WT (n=10) and BRCA1mut/+ (n=10) breast tissues. Allred score methodology was used to measure SIRT1 antibody staining. Student’s two-tailed t-test was used to calculate P value. (*) indicates P value within the 0.05 level of significance. (b) Model of tissue- and cell-type-specific response to BRCA1 haploinsufficiency. Scale bar, 10 μm.

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