Figure 6: Targeting c-Myc is a mechanism by which 14-3-3σ suppresses cancer metabolic reprogramming. | Nature Communications

Figure 6: Targeting c-Myc is a mechanism by which 14-3-3σ suppresses cancer metabolic reprogramming.

From: The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming

Figure 6

(a) c-Myc expression was knocked down in MDA-MB-231 TetR 14-3-3σ breast cancer cells. (b,c) c-Myc knockdown hindered 14-3-3σ-mediated suppression of cancer metabolic reprogramming. MDA-MB-231 TetR 14-3-3σ cells infected with luciferase shRNA, c-Myc shRNA #1614 or c-Myc shRNA #1657 were treated with doxycycline to induce Flag-14-3-3σ expression (+). Noninduced cells were used as a control (−). ECAR and OCR were measured as previously described. Bars represent means±95% CI; Student’s t-test, *P<0.05.

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