Figure 8: The multimodality comparison for in vivo early detection of small tumour lesions.
From: In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging
(a) Sixty-five hours after tumour cell injection, a white light image shows a small tumour lesion (red arrow). (b) BLI confirms the location of the small tumour lesion. (c) Axial PET shows false-negative scan. (d,e) With no filtering and 620 nm filtering, CLI (right mouse) shows false-negative detection (black arrows), but REFI (left mouse) shows true-positive detection (red arrows). (f) FMI of untargetted QD620 shows multiple suspected lesions, and targeted RJ2-DG750 shows overestimation of the tumour region. The signal-to-background ratios of both fluorescent probes are significant lower than that of REFI.
