Table 1 Mouse strains/models of IBD examined in this study.
Strain | Breeding source | Reported digestive disease phenotype | Main reported and studied GI disease phenotypes | SM Cobblestones | Other SM lesions |
|---|---|---|---|---|---|
A/J | Jackson | No* | No | Yes | |
AKR/J | Jackson, CWRU | No* | No | Yes | |
BALB/C | Jackson | No* | No | Yes | |
CBA/J | Jackson | No* | No | Yes | |
C3H/HEJ | Jackson | No* | No | Yes | |
C57BL6/J | Jackson | No* | No | Yes | |
C57BL6/NJ | CWRU | No* | No | Yes | |
C57BL6/NJredfoxp3 | Jackson | No* | No | Yes | |
DBA/2J | Jackson | No* | No | Yes | |
SCID | CWRU | No* | No | Yes | |
FVB/NJ | Jackson | No* | No | Yes | |
FVB/129P2mdr1a−/− | Taconic | Yes, spontaneous | Colitis | No | Yes |
C57BL/6JTNFΔARE/+ | CWRU | Yes, spontaneous | Ileitis, arthritis | No | Yes |
C57BL/6J.129STNFΔARE/+ | CWRU | Yes, spontaneous | Ileitis, arthritis | No | Yes |
SAMP1 | CWRU | Yes, spontaneous | Ileitis, | Yes | Yes |
SAMP1/YitFc | CWRU | Yes, spontaneous | Ileitis | Yes | Yes |
SAMP1/YitFc NOD2−/− | CWRU | Yes, spontaneous | Ileitis | Yes | Yes |
SAMP1/YitFc—Germ-free | CWRU/Taconic | Yes, spontaneous | Ileitis | Yes | Yes |
Consomic SAMP with single replacement of C57BL6/J-derived of chromosomes X, 6, 8, and 9 | CWRU | Yes, spontaneous | Ileitis | Yes | Yes |
SAMP6 | Harlan, CWRU | Yes, spontaneous | Colitis | No | Yes |
DSS-induced | CWRU | Inducible | Colitis | — | Yes |
AOM/DSS induced | CWRU | Inducible | Colitis | — | Yes |
RBhigh into SCID induced | CWRU | Inducible | Colitis | — | Yes |
