Figure 1: Experimentally determined conformational changes in the cyclic nucleotide-binding domain.
From: Allostery through the computational microscope: cAMP activation of a canonical signalling domain
(RIα a.a. 119 to 244) in cAMP bound active, right and holoenzyme inactive, left, with key signalling structural subdomains highlighted: PBC, red; B/C helix, ice blue; and N3A motif, ochre.
