Table 1 Mean first passage time between active and inactive conformations.

From: Allostery through the computational microscope: cAMP activation of a canonical signalling domain

System

Without cAMP

With cAMP

 

A→I (μs)

A←I (μs)

A→I (μs)

A←I (μs)

CBD

16.1

34.0

83.7

30.3

PBC

2.9

0.9

4.9

0.2

B/C Helix

8.2

13.4

24.3

10.6

N3A

1.3

2.9

2.2

1.6

  1. cAMP, cyclic AMP; CBD, cyclic nucleotide-binding domain; PBC, phosphate-binding cassette.
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