Table 2 Population and half-life for CBD–Apo and CBD–cAMP coarse-grain functional states.

From: Allostery through the computational microscope: cAMP activation of a canonical signalling domain

Macrostate

CBD–Apo population (%)

t1/2 mean (s.d.; μs)

Macrostate

CBD–cAMP population (%)

t1/2 mean (s.d.; μs)

Active

36

2.29 (0.09)

Active

77

36.59 (1.12)

Inactive

64

8.62 (0.41)

Inactive

23

7.41 (0.45)

  1. cAMP, cyclic AMP; CBD, cyclic nucleotide-binding domain.