Figure 1: Bilateral lesions of the PL attenuate CFA-induced heat hyperalgesia and anxiety-like behaviours. | Nature Communications

Figure 1: Bilateral lesions of the PL attenuate CFA-induced heat hyperalgesia and anxiety-like behaviours.

From: Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety

Figure 1

(a) Paw withdrawal latency of the contralateral and ipsilateral hind paws after CFA injection (n=5 animals, *P<0.05, ***P<0.001, two-way ANOVA with Bonferroni post tests). (b) Elevated plus maze (left and middle, n=6, 7 animals, *P<0.05, **P<0.01, two-tailed t-test) and open field test (right, n=7, 9 animals, **P<0.01, two-tailed t-test) 1 day after CFA injection. (c) Locomotor activity 1 day after CFA injection (n=7, 9 animals, two-tailed t-test). (d) Elevated plus maze (left and middle, n=6, 6 animals, *P<0.05, two-tailed t-test) and open field test (right, n=5, 7 animals, *P<0.05, two-tailed t-test) 7 days after CFA injection. (e) Locomotor activity 7 days after CFA injection (n=5, 7 animals, two-tailed t-test). (f–h) Paw withdrawal latency, elevated plus maze, open field test and locomotor activity of the CFA rats after bilateral lesion of the PL, IL or CG1 by quinolinic acid, respectively (*P<0.05, two-tailed t-test). The data are presented as mean±s.e.m.

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