Figure 4: Transmission of the cell-cycle arrest signal at the mitosis and lineage scale.
From: Two routes to senescence revealed by real-time analysis of telomerase-negative single lineages
(a,b) Scatter plots of cell-cycle duration in pairs of sister cells (mother cell and new daughter) in TetO2-TLC1 (a) type A lineages (n=141 pairs from three independent lineages) and (b) type B lineages (n=131 pairs from three independent lineages). Correlation coefficients (95% CI) between the pairs are (a) r=0.97 (0.96; 0.98) and (b) r=0.73 (0.64; 0.80). (c) Autocorrelation functions of cell-cycle durations in the indicated strains treated with or without doxycycline. Telomerase-negative lineages, particularly type B cells, show stronger autocorrelation than telomerase-positive cells. Mec1 deficiency suppresses memory.
