Figure 6: Exogenous adiponectin improves the psoriasiform dermatitis in Adipo knockout (KO) mice.

Wild-type (WT) and Adiponectin knockout (Adipo KO) mice were given daily intraperitoneal (i.p.) injection of recombinant adiponectin (50 μg per day) from day 1 before imiquimod (IMQ) treatment. (a) Phenotypical manifestation of WT and Adipo KO mouse back skin induced by IMQ at day 5 with or without exogenous adiponectin administration. (b) Disease severity (left panel) and ear thickness (right panel) during IMQ treatment. Clinical scores for disease severity were calculated as described in the Methods. Data are presented as mean±s.e. (n=4 for each group). *P<0.05 versus Adipo KO mice without adiponectin administration. Data are analysed by Welch’s t-test. (c) Histological presentation of WT and Adipo KO mouse back skin induced by IMQ at day 5 with or without exogenous adiponectin administration. Scale bar, 50 μm. (d) IL-17 mRNA expression of WT and Adipo KO mouse back skin induced by IMQ at day 2 with or without exogenous adiponectin administration. Data are analysed by one-way analysis of variance with Dunnett’s multiple comparison test.