Figure 7: Adipo knockout (KO) mice need a further dose of anti-IL-17 antibody to prevent the psoriasiform dermatitis.
From: Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from γδ-T cells
Wild-type (WT) and Adipo KO mice were intraperitoneally injected with control IgG, or 10 and 80 μg of anti-IL-17 antibody (IL-17 Ab) at 1 day before (day −1) and 2 days after (day 2) imiquimod (IMQ) treatment. (a) Phenotypical manifestation of WT and Adipo KO mouse back skin induced by IMQ at day 5. (b) Disease severity (upper panel) and ear thickness (lower panel) during IMQ treatment. Clinical scores for disease severity were calculated as described in the Methods. Data are presented as mean±s.e. (n=4 for each group). *P<0.05 versus WT mice with IMQ application. Data are analysed by Welch’s t-test. (c) Histological presentation of WT and Adipo KO mouse back skin induced by IMQ at day 5 with the indicated dose of IL-17 antibody injection. Scale bar, 50 μm.
