Table 1 KEGG pathway analysis of the deregulated genes identified by microarray and RNA-sequencing after downregulation of MEG3 and EZH2 by siRNA in BT-549 cells using GeneSCF.
KEGG-ID | KEGG pathways | MEG3 ( P value) | EZH2 ( P value) | ||
---|---|---|---|---|---|
Microarray | RNA-seq | Microarray | RNA-seq | ||
hsa05200 | PI3K-Akt signalling pathway | 0.0000000307 | 0.00036 | 0.0001 | 0.00000376 |
hsa04390 | Proteoglycans in cancer | 0.000000472 | 0.00494 | 0.00000787 | 0.0021 |
hsa05166 | Pathways in cancer | 0.00000099 | 0.000000697 | 0.00000808 | 0.002 |
hsa04350 | TGF-beta signalling pathway | 0.0000059 | 0.0000893 | 0.00000062 | 0.0002 |
hsa05205 | HTLV-I infection | 0.00000865 | 0.00000239 | 0.0002 | 0.0432 |
hsa04151 | Focal adhesion | 0.0000188 | 0.00076 | 0.0005 | 0.0000239 |
hsa04910 | Insulin signalling pathway | 0.0000246 | 0.0175 | 0.0087 | 0.0274 |
hsa04510 | Hippo signalling pathway | 0.0000867 | 0.000002029 | 0.0001 | 0.0022 |
hsa01100 | Colorectal cancer | 0.0001 | 0.0017 | 0.000029 | 0.0009 |
hsa05414 | Regulation of actin cytoskeleton | 0.0003 | 0.0001 | 0.0012 | 0.0000114 |
hsa04010 | Endocytosis | 0.0005 | 0.0000187 | 0.0002 | 0.0002 |
hsa00532 | Pancreatic cancer | 0.0008 | 0.01 | 0.0002 | 0.0000439 |
hsa04668 | Hypertrophic cardiomyopathy | 0.0013 | 0.00000569 | 0.0053 | 0.0238 |
hsa05203 | Chagas disease | 0.0013 | 0.0028 | 0.000022 | 0.0054 |
hsa04520 | Adherens junction | 0.0016 | 0.0002 | 0.000079 | 0.0005 |
hsa05142 | Viral carcinogenesis | 0.0017 | 0.0144 | 0.0082 | 0.0177 |
hsa05410 | TNF signalling pathway | 0.0019 | 0.00107 | 0.0052 | 0.0001 |
hsa05212 | Glycosaminoglycan biosynthesis | 0.0027 | 0.002 | 0.0311 | 0.0136 |
hsa04144 | MAPK signalling pathway | 0.0062 | 0.0004 | 0.014 | 0.0001 |
hsa04810 | Dilated cardiomyopathy | 0.02 | 0.0000489 | 0.0013 | 0.0289 |
hsa05210 | Metabolic pathways | 0.04 | 0.0269 | 0.0009 | 0.0216 |