Figure 4: Comparison of open glucagon-bound and -closed apo-GCGR structures.
From: Conformational states of the full-length glucagon receptor
(a) Representative snapshots of glucagon-bound GCGR (confopen, blue) and apo-GCGR (confclosed, red) in the MD simulations (defined in Fig. 3). Regions investigated in HDX studies (see Fig. 2 and Table 1) are coloured dark (red/blue) and shown in more detail in (b) the top region of the stalk; (c) the N terminus of the ECD; (d) ECL1; and (e) ECL3. Residues involved in specific interactions or adopting different conformations in glucagon-bound and apo-GCGRs are depicted as sticks.
