Figure 4: Quantitation of histone H3 crosslinked peptides with PTMs.
From: Quantitative interactome analysis reveals a chemoresistant edgotype
(a) Map of intra-protein crosslinked peptide pairs from histone H3 (H31_Human) that were quantified with a Log2(Resistant/Sensitive) magnitude >1 with a 95% CI <1. Crosslinked residues are indicated by red bold. Residue numbering is according to canonical histone PTM nomenclature (UniProt-1)38 (b) Extracted ion chromatograms for the isotopically light and heavy crosslinked peptide pair linking K18 with K36 and containing acetylation modifications on K23 and K27. (c) Extracted ion chromatograms for the isotopically light and heavy crosslinked peptide pair linking K23 with K37 and containing dimethyl modifications on K27 and K36.
