Figure 1: The expressions of TRB3 and pIRS-1 positively correlate with poor prognosis of human cancers. | Nature Communications

Figure 1: The expressions of TRB3 and pIRS-1 positively correlate with poor prognosis of human cancers.

From: TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

Figure 1

(a–c) Expression of TRB3 or pIRS-1 was detected with immunohistologic staining in tumour and adjacent non-tumour tissues of the human liver (a), colon (b) and lung (c). Data are representative of stained tumour and adjacent non-tumour tissues (left; scale bar, 20 μm) with quantized analyses of paired clinical samples (right). The sample size is indicated in the quantify graphs. Statistical significance was determined by Student’s t-test; **P<0.01, ***P<0.001. (d–f) Kaplan–Meier plot of overall survival of patients with HCC (d), colon cancer (e) and lung cancer (f) stratified by TRB3 or pIRS-1 expression level. Tissues were scored as low (<20% TRB3 or pIRS staining for all tumour cells) and high (TRB3 or pIRS-1 staining >20% for all tumour cells or strong staining for >5% tumour cells). The sample size is indicated in the quantify graphs. A log-rank test is used for statistical analysis. *P<0.05; **P<0.01; ***P<0.001.

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