Figure 3: Schematic illustration of the topology of the TRPV5 protein
From: Common and rare variants associated with kidney stones and biochemical traits
The TRPV5 p.L530R mutation occurs within the pore-forming region (amino acids 527–538) of the ion transport domain (amino acids 389–578) of TRPV5 replacing a hydrophobic with a basic amino acid. Acidic and basic amino acids as red and blue, respectively.
