Table 1 Summary information for the lead regional sequence variants associating with kidney stone.

From: Common and rare variants associated with kidney stones and biochemical traits

SNP ID

Position (Hg18)

A

MAF (%) ice/1Keu

Locus

Kidney stones

Recurrent kidney stones

Mechanism

     

P

OR

P

OR

 

rs199565725

chr21:36757108

A/AAC

23.68/23.20

CLDN14

4.7 × 10−13

0.81

3.5 × 10−9

0.77

Cell–cell adhesion

rs12654812

chr5:176726797

A/G

41.84/34.78

SLC34A1

5.7 × 10−11

1.18

4.4 × 10−7

1.21

Na/Pi co-transporter

rs1256328

chr1:21769354

T/C

17.79/17.32

ALPL

5.8 × 10−10

1.21

4.0 × 10−6

1.23

Alkaline phosphatase

rs7627468

chr3:123428789

A/G

26.80/24.02

CASR

2.0 × 10−8

1.16

4.1 × 10−5

1.18

Ca-sensing G-protein-coupled receptor

  1. A, allele (minor/major); MAF, minor allele frequency (ice, Iceland; 1Keu, 1000 genomes European Americans); OR, odds ratio.
  2. Reported are the three genome-wide significant (P<1.8 × 10−9) sequence variants (rs199565725, rs12654812 and rs1256328) and in addition one suggestive sequence variant (rs7627468) associating with kidney stone in Iceland.
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