Table 2 Kidney stone associated biochemical traits.

Trait ^*	N (KS cases)	*CLDN14* rs199565725[T]		*SLC34A1* rs12654812[A]		*ALPL* rs1256328[T]		*CASR* rs7627468[A]
		P	Effect (s.d.%)	P	Effect (s.d.%)	P	*Effect* (s.d.%)	P	Effect (s.d.%)
Calcium–phosphate metabolism
ALP	126,060 (3,869)	0.30	−0.6	0.037	1.1	2.2 × 10 ⁻³²	7.8	0.92	0.1
PTH	15,541 (1,003)	1.1 × 10 ⁻⁴	−4.5	2.3 × 10 ⁻⁹	−5.9	0.62	−0.6	0.13	1.7
25-OH VD	7,544 (377)	0.72	0.7	0.87	0.3	0.38	−1.7	7.5 × 10⁻³	−4.6
Purine metabolism
Uric Acid	56,025 (2,667)	0.20	−1.0	0.090	1.1	0.56	−0.5	0.59	0.4
Acid–base homeostasis
Bicarbonate	44,511 (1,576)	0.60	0.4	0.15	0.1	0.50	0.6	0.61	0.4
Kidney function
Creatinine	195,933 (4,911)	0.17	−0.6	5.4 × 10 ⁻⁸	0.2	0.95	0.1	0.45	0.3
Ion homeostasis
Calcium	114,489 (3,842)	0.34	0.5	0.012	1.1	0.79	−0.1	1.1 × 10⁻³	1.6
Calcium ionized	18,516 (1,129)	0.57	−0.5	0.026	1.8	0.63	0.5	6.0 × 10⁻³	2.5
Chloride	92,938 (3,228)	0.61	0.3	0.81	−0.1	0.09	−0.1	0.26	0.6
Magnesium	37,188 (1,472)	2.0 × 10 ⁻⁷	4.0	0.27	0.7	0.53	0.5	0.36	−0.7
Phosphate	51,056 (2,228)	0.11	1.0	1.1 × 10 ⁻¹⁴	−4.2	0.71	−0.3	0.01	−1.5
Potassium	201,720 (4,980)	8.2 × 10 ⁻⁴	−1.2	0.65	−0.1	0.80	0.1	0.05	0.7
Sodium	198,119 (4,951)	0.39	−0.3	0.019	0.8	0.41	0.3	0.11	−0.6

ALP, alkaline phosphatase; PTH, parathyroid hormone, 25-OH VD, 25-hydroxy vitamin D; N, number of individuals with genotype information with quantitative traits measurements
Association of genome-wide significant and suggestive kidney stone sequence variants with biochemical traits involved in calcium–phosphate metabolism, purine metabolism, kidney function, acid–base and ion homeostasis.
Underlined are P values reaching a significant threshold for the number of tests performed (0.05/52=9.6 × 10⁻⁴). The number of kidney stone cases in each group is indicated within brackets.
^*All measurements are obtained from serum.

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