Figure 1: Preservation of rod photoreceptors by HDAC4 deletion alleles in rd1 mice. | Nature Communications

Figure 1: Preservation of rod photoreceptors by HDAC4 deletion alleles in rd1 mice.

From: A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa

Figure 1

(a) Schematic representation of HDAC4 functional domains and HDAC4 deletion alleles. (b) Co-electroporation of CAG-GFP (transfection marker), CAG-HDAC4 Full Length, and a rhodopsin reporter construct, Rho-DsRed, in the P0 rd1 retinas with assay at P50 for anti-rhodopsin immunoreactivity. Scale bar, 40 μm. (c) Rho-DsRed+ rods saved by HDAC4 deletion alleles at P50 in the rd1 retina. Scale bar, 40 μm. (d) Quantification of rod survival by HDAC4 Full Length and HDAC4 deletion alleles. Rho-DsRed-positive cells were scored per 25,600 μm2 in transfected areas. *P<0.01. Data are presented as mean±s.d., n=5–8.

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