Figure 7: Construction of HDAC4* transgenic mice. | Nature Communications

Figure 7: Construction of HDAC4* transgenic mice.

From: A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa

Figure 7

(a) Schematic representation of HDAC4* transgenic construct design. (b) Immunoblotting analysis of transgene expression in rd1;HDAC4* transgenic mice at P10. (c–f) Immunohistochemistry analysis of transgene expression in rd1;HDAC4* transgenic mice at P10 on retinal sections. Scale bar, 20 μm. (c,d) Detection of HDAC4 immunoreactivity and the GFP reporter. (e) Arrows: transgene expression in rods labelled by anti-rhodopsin immunohistochemistry. (f) Arrows: transgene expression in cones labelled by red/green cone opsin immunohistochemistry. Full scan images of western blot data are provided in Supplementary Fig. 10.

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