Figure 7: Differential trafficking of autonomously activated EphA2 versus ligand-activated EphA2. | Nature Communications

Figure 7: Differential trafficking of autonomously activated EphA2 versus ligand-activated EphA2.

From: Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode

Figure 7

Cyclic trafficking of EphA2 via the perinuclear pool of active PTPs acts as a safeguard mechanism against its autonomous activation (left). Ligand-induced clustering and docking of c-Cbl mediates receptor ubiquitination and unidirectional trafficking through the sorting endosomes/MVBs towards the late endosomes/lysosomes, thereby ensuring a transient response to growth factors (right). Lower left box: abbreviations and symbols.

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