Figure 1: Afferent inputs to coincidence detection neurons of the MSO and LSO. | Nature Communications

Figure 1: Afferent inputs to coincidence detection neurons of the MSO and LSO.

From: Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing

Figure 1

(a) Simplified schematic of the mammalian ITD- and ILD-detection circuit. (b) Aligned projections of confocal image stacks from transverse brainstem slices at the level of the trapezoid body. GBC axons were anterogradely traced with tetramethylrhodamine dextran. Three individual fibres are highlighted in colour. (c) Magnification of a GBC axon segment (red) including two nodes of Ranvier (arrowheads). The position of juxtaparanodal immunolabelled Kv1.2 channels is shown in green. (d) Internode length in GBC and SBC axons plotted against the distance from the heminode and the branching area in the MSO, respectively. (e) The mean internodal axon diameter is significantly larger in GBC axons than in SBC axons (P<0.001; Mann–Whitney test). (f) The mean internode length is larger in GBC axons than in SBC axons (P=0.005, t-test). For GBC and SBC axons, the mean INL was calculated from internodes located >700 μm away from the heminode and from internodes located >500 μm away from the MSO, respectively (dashed lines in d). Numbers on bars are of internodes in 17 GBC and 7 SBC axons. Data in e,f are represented as mean±s.e.m. Scale bars, 1,000 μm (b) and 100 μm (c).

Back to article page