Figure 5: Computer simulations exploring the effect of morphological parameters on action potential propagation in SBC and GBC axons. | Nature Communications

Figure 5: Computer simulations exploring the effect of morphological parameters on action potential propagation in SBC and GBC axons.

From: Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing

Figure 5

(a) Dependence of conduction velocity on L/d ratio in GBClat, GBCmed and SBC axons. For GBClat, GBCmed and SBC axons the internodal diameters were fixed at 3.06, 2.40 and 1.35 μm, respectively, and the nodal diameters were fixed at 1.68, 1.50 and 0.85 μm. At low L/d ratios the conduction velocity decreases because a smaller fraction of the axon is myelinated, while at long internode lengths it decreases because of inefficient transfer of depolarization between nodes. Solid arrows indicate the experimentally determined L/d ratios. Dashed arrow shows extra simulated L/d ratio for GBClat. (b–d) Dependence of the maximum rate of rise (b), half-width (c) and amplitude (d) of the simulated axonal AP on L/d ratios in GBCmed and GBClat fibres. Vertical lines indicate the experimentally observed L/d ratios in GBCmed and GBClat fibres.

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