Figure 1: Regional plot of the four identified lead SNPs.
From: Association analysis identifies new risk loci for congenital heart disease in Chinese populations
These SNPs are (a) rs1400558 at 4q31.22, (b) rs7863990 at 9p24.2, (c) rs2433752 at 12q24.13 and (d) rs490514 at 20q12. The results (−log10 P) are shown for the SNPs located in the 600-kb region flanking either side of the marker SNPs in the GWA scan stage. Genetic association testing was performed using logistic regression analyses under an additive model. First principal component was adjusted in GWA scan stage. The marker SNPs are shown as purple circles with their P values in GWA scan stage and as purple diamonds with their P values in the combined stage when all of the CHD cases and non-CHD controls from the GWA scan and Validations I, II and III were pooled together. The r2 values of the remaining SNPs are indicated by different colours. The genes within the region-of-interest are annotated, with arrows indicating the direction of transcription. For each plot, the recombination rates (right y-axes) of the region are shown according to their chromosomal positions (x-axis).
