Figure 4: Simultaneous binding of EE2 and TNC to PXR. | Nature Communications

Figure 4: Simultaneous binding of EE2 and TNC to PXR.

From: Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

Figure 4

Mass spectrometry analysis. Non-denaturing ESI-MS was used to characterize PXR LBD (10 μM) in (a) the unliganded form or in the presence of (b) EE2 (20 μM), (c) TNC (20 μM), or (d) a mixture of EE2 (20 μM) and TNC (20 μM). *, acetate adducts; $, fortuitous binders 254-324 Da; , fortuitous binder 254 Da; #, non-specific EE2 adducts.

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