Figure 5: Characterization of distal edQTLs.

(a) QTL effect sizes for 45 proximal edQTLs within the edited dsRNA and 213 distal edQTLs outside of the edited dsRNA. Effect sizes were calculated as half of the absolute value of the difference in average editing levels between the two homozygotes for each edQTL. Proximal edQTLs have significantly greater effect sizes (one-sided Mann–Whitney U-test). (b) Frequency of RNA editing sites nearby 213 distal edQTLs and 4247 matched control variants. For each variant, we calculated the number of RNA editing sites within sequence windows centred on the variant. (c) Distances from the editing sites to 28 dsRNA stems around distal edQTLs.