Table 1 Risk and eQTL associations in serous ovarian cancer.

From: Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Locus

Risk associations

eQTL associations

r 2

 

rsID

OR

P value (1 df)

EAF

rsID

Gene

Stat

Unadjusted P value

FDR

 

2q31

rs6755777

1.15

8.95 × 10−14

0.68

rs711830

HOXD9

3.48

5.82 × 10−4

0.03

0.99

1p36

rs72665317

0.89

6.83 × 10−7

0.16

rs2268177

CDC42

−7.46

8.40 × 10−13

9.07 × 10−11

0.88

     

rs7412010

CDC42

7.38

1.36 × 10−12

9.07 × 10−11

0.78

1p34

rs4335340

0.90

1.37 × 10−7

0.25

rs12023270

CDCA8

3.22

1.41 × 10−3

0.05

0.61

20q13

rs6026494

1.16

5.07 × 10−7

0.11

rs6026494

GNAS

2.96

3.28 × 10−3

0.09

1.00

  1. EAF, effect allele frequency; OR, odds ratio; Stat, T-statistic.
  2. r2 values between risk SNP and eQTL SNP are from 1000 Genomes Phase 1 EUR population. Risk associations from an OCAC-only analysis.
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