Table 3 Enrichment of HGSOC risk variants in regulatory regions of HOXD9 target genes.
Cell type | Ovarian HOXD9 target genes* (n =128) | Fallopian HOXD9 target genes* (n =34) | |||||||
|---|---|---|---|---|---|---|---|---|---|
Gene ±extended boundaries | 10 kb | 25 kb | 50 kb | 100 kb | 10 kb | 25 kb | 50 kb | 100 kb | |
K–S test | 4.2 × 10−4 | 0.004 | 0.006 | 3.9 × 10−6 | 0.001 | 3.7 × 10−6 | 2.4 × 10−7 | 5 × 10−6 | |
Fisher’s exact test threshold | P<10−3 | 4.9 × 10−10 | 7.9 × 10−14 | 1.9 × 10−18 | 5.2 × 10−14 | 1.1 × 10−15 | 3 × 10−11 | 4.4 × 10−13 | 3.4 × 10−9 |
P<10−4 | 6 × 10−10 | 8.5 × 10−14 | 1.2 × 10−20 | 1.2 × 10−31 | 5 × 10−20 | 8.5 × 10−17 | 1.1 × 10−21 | 3.8 × 10−16 | |
P<10−5 | No SNPs | No SNPs | No SNPs | No SNPs | 0.876 | 0.779 | 0.178 | 0.005 | |
