Figure 1: Myocardial COUP-TFII expression causes dilated cardiomyopathy (DCM). | Nature Communications

Figure 1: Myocardial COUP-TFII expression causes dilated cardiomyopathy (DCM).

From: Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure

Figure 1

(a) COUP-TFII mRNA levels in human heart tissues of non-failing (NF, n=6) and idiopathic DCM (n=13) from GSE1869. (b) Strategy of inducible COUP-TFII expression in adult mouse myocardium. (c) Gross view of day 16 hearts. The scale of rulers underneath the whole mount images is 1 mm. (d,e) Time-coursed echocardiogram. Day 0 indicates the day before induction of COUP-TFII expression. LVIDd, left ventricular interior dimension at diastole. N=5 (CTRL) and 7 (OE). (f) Survival rate of nine CTRL and eight OE mice over time. (g) Manifestation of the COUP-TFII gene signature in human heart samples (GSE1869). COUP-TFII gene signature is curated from all COUP-TFII downstream targets in mouse hearts that are identified by the microarray analysis. (h) Major biological processes altered by COUP-TFII overexpression identified by the Ingenuity pathway analysis. ***P<0.001 (t-test) between CTRL and OE. Error bars denote the standard error of the mean (s.e.m.).

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