Figure 10: Model of Del-1 regulation. | Nature Communications

Figure 10: Model of Del-1 regulation.

From: Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway

Figure 10

IL-17 downregulates Del-1 expression through a GSK3β- and C/EBPβ-dependent mechanism, which inhibits the binding of the critical transcription factor C/EBPβ to the EDIL3 promoter. This inhibitory action of IL-17 is counteracted at the GSK3β level by D-series resolvins in a PI3K/Akt-dependent manner. In stark contrast to IL-17, IFNγ enhances the binding of C/EBPβ to the EDIL3 promoter and upregulates Del-1 expression.

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