Figure 5: LRF stabilizes the Ku/DNA-PKcs complex on DNA breaks.
From: LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair
(a) DNA-PK kinase activity was assessed in total cell extracts from Arf−/− control (Arf−/− Lrff/f con) and Arf−/− LRF-deleted MEF (Arf−/− Lrff/f Cre). (b) Clonogenic survival of p53−/− Lrf+/+ and p53−/− Lrf−/− MEF after different doses of γ-radiation. (c) Schematic representation of LRF function in NHEJ DSBs repair pathway. Data are presented as mean±s.e.m. of three independent experiments. Associated P value calculated by Student’s t-test analysis is indicated.
