Figure 1: Pedigrees of TP53-negative LFL families. | Nature Communications

Figure 1: Pedigrees of TP53-negative LFL families.

From: A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li–Fraumeni-like families

Figure 1

Families 1, 2 and 3 have three, two and one members with cardiac angiosarcomas (CAS), respectively. CAS and other tumours are shown (colour code below the Fig.). Exomes of blue-squared CAS cases were sequenced. One member of family 4 presented with breast angiosarcoma. Only family members of whom DNA samples were available are numbered (1–19) in bold and italics. Age of onset (CAS cases) and age of sample (mutation carriers) is shown in brackets. Age of onset of other tumours is shown in the Table 1. ‘*’ indicates immortalized lymphocyte cell lines from family 1: II-1 and II-4 (64- and 65-years old, respectively) and III-15 and III-16 (34- and 35-years old, respectively). ‘**’ indicates paraffin-embedded tumour tissue available. Black arrows show the probandus for each family.

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