Figure 3: Slope and IC50 characteristics of CD4 immunoadhesins. | Nature Communications

Figure 3: Slope and IC50 characteristics of CD4 immunoadhesins.

From: Dose–response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies

Figure 3

Neutralization slopes (a) and IC50s (b) of the CD4bs bnAbs combined and CD4 immunoadhesin reagents sCD4, CD4-Ig and eCD4-Ig. Slope and IC50 values for CD4bs bnAbs and sCD4 are from Fig. 2 and reproduced here for ease of comparison. Slopes for CD4-Ig and eCD4-Ig were estimated from published IC50 and IC80 values42 using equation (6) (Methods). Thus, slopes were only estimated for a subset of Envs (n=14) where discrete IC50 and IC80 values were reported. Bars represent geometric mean IC50 with 95% CI or mean slope with 95% CI and P value (one-way ANOVA) compares slopes of CD4bs bnAbs with sCD4, CD4-Ig and eCD4-Ig combined in panel a, all other P values are Student's t-test.

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