Figure 5: O-GlcNAcylation of G6PD is important for tumor growth in vivo and is increased in human lung cancers.
From: O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth
(a) Tumor formation in nude mice (n=11) injected with WT or S84V G6PD replacement A549 cells. (Left) Dissected tumours after 7 weeks of growth in mice injected with WT replacement cells on the right flank and S84V replacement cells on the left flank. (Right) Masses of the dissected tumours. (b) Detection of G6PD O-GlcNAcylation and OGT expression in human lung tumor (T) tissues and the matching adjacent normal (N) tissues. (c–e) The statistical analysis of 16 paired tumor and normal samples. Relative G6PD glycosylation level was normalized to the total G6PD protein level for each patient. Statistical analysis was performed by paired Student’s t-test (*P<0.05, **P<0.01). NS, not significant.
