Table 1 Summary results of meta-analysis and replication studies for prostate cancer.

From: Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer

SNP

Allele *

Chr

Position †

Gene ‡

Study

Population

EAF §

OR

P value

P het ||

rs4749884

C/A

10p14

9644800

—

Japanese GWAS

Japanese

0.533

1.14

2.29E−03

 
     

Chinese GWAS

Chinese

0.434

1.18

6.49E−03

 
     

Meta-analysis GWAS

  

1.15

4.74E−05

0.673

     

Shanghai

Chinese

0.437

1.15

4.87E−03

 
     

Nanjing

Chinese

0.446

1.09

1.68E−01

 
     

MEC

Japanese

0.460

0.97

6.41E−01

 
     

Meta-analysis of all studies

  

1.12

6.68E−06

0.100

rs12791447

C/T

11p15.4

7556577

PPFIBP2

Japanese GWAS

Japanese

0.136

1.23

7.66E−04

 
     

Chinese GWAS

Chinese

0.086

1.35

3.13E−03

 
     

Meta-analysis GWAS

  

1.26

1.05E−05

0.421

     

Shanghai

Chinese

0.098

1.27

2.73E−03

 
     

Nanjing

Chinese

0.095

1.29

8.89E−03

 
     

MEC

Japanese

0.138

1.01

8.97E−01

 
     

Meta-analysis of all studies

  

1.23

3.59E−08

0.177

rs75718479

C/A

12q23.1

97876906

RMST

Japanese GWAS

Japanese

0.877

1.26

6.50E−04

 
     

Chinese GWAS

Chinese

0.910

1.32

7.75E−03

 
     

Meta-analysis GWAS

  

1.28

1.71E−05

0.732

     

Shanghai

Chinese

0.906

1.22

2.49E−02

 
     

Nanjing

Chinese

0.902

1.31

1.35E−02

 
     

MEC

Japanese

0.887

0.98

8.23E−01

 
     

Meta-analysis of all studies

  

1.22

1.12E−06

0.111

rs58262369

C/T

14q23.2

64693912

ESR2

Japanese GWAS

Japanese

0.928

0.73

1.40E−04

 
     

Chinese GWAS

Chinese

0.889

0.72

8.04E−04

 
     

Meta-analysis GWAS

  

0.73

3.83E−07

0.929

     

Shanghai

Chinese

0.898

0.77

1.05E−03

 
     

Nanjing

Chinese

0.898

0.78

7.38E−03

 
     

MEC

Japanese

0.929

1.00

9.87E−01

 
     

Meta-analysis of all studies

  

0.78

6.05E−10

0.149

  1. EAF, effect allele frequency; GWAS, genome-wide association study; MEC, Multiethnic Cohort; OR, odds ratio; SNP, single-nucleotide polymorphism.
  2. *Effect/non-effect allele.
  3. †On the basis of the National Center for Biotechnology Information (NCBI) database, build 37.
  4. ‡Nearby gene.
  5. §Effect allele frequency in the controls.
  6. ||P value of Cochran’s Q-test for the heterogeneity.
Back to article page