Figure 1: AML LSCs and Blasts exhibit epigenetic differences that define an LSC epigenetic signature. | Nature Communications

Figure 1: AML LSCs and Blasts exhibit epigenetic differences that define an LSC epigenetic signature.

From: An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis

Figure 1

Plots of DMRs indicating genomic loci for REC8 (a), HOXA9 (b), HOXA7 (c) and HOXA10 (d), four LSC epigenetic signature genes that are hypomethylated and upregulated in LSC. Top: level of CpG methylation (Beta) of each sample for the region; middle: CpG density (curve), CpG sites (black tick marks) and CpG islands (red lines); bottom: gene annotation.

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