Figure 2: The LSC epigenetic signature is partially dependent on underlying somatic mutations. | Nature Communications

Figure 2: The LSC epigenetic signature is partially dependent on underlying somatic mutations.

From: An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis

Figure 2

Shown is a schematic flow chart of mutation association analysis. We compared our LSC epigenetic signature with the mutation-specific DMRs obtained from TCGA data set. The LSC epigenetic signature was classified into three different groups, and each DMR is shown in this diagram. Note that several genes such as HOXA9 have multiple DMRs and different DMRs in one gene are annotated with DMR number such as HOXA9/DMR1. Genes associated with mutation in both upstream regulators and epigenome modifying enzymes are marked with `*'.

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