Figure 5: Comprehensive DNA methylation analysis shows tight clustering of individual HSPC populations. | Nature Communications

Figure 5: Comprehensive DNA methylation analysis shows tight clustering of individual HSPC populations.

From: An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis

Figure 5

(a) Multidimensional scaling examining the top 1,000 most variable methylation positions among HSPC populations shows tight clustering of distinct lineages. (b) DMR plots show genomic loci for newly identified genes with previously unknown functions in haematopoiesis. The examples are HMHB1 and MIR539. Top: level of CpG methylation (Beta) of each sample for the region; middle: CpG density (curve), CpG sites (black tick marks) and CpG islands (red lines); bottom: gene annotation; lower panel: bisulfite pyrosequencing replicating the methylation value for individual CpGs in the red boxes.

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