Figure 6: Epigenetic signatures define subgroups of AML LSC reflecting the cell of origin. | Nature Communications

Figure 6: Epigenetic signatures define subgroups of AML LSC reflecting the cell of origin.

From: An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis

Figure 6

(a) A total of 216 DMRs identified from all possible pairwise comparisons among six HSPCs were used to cluster all normal HSPCs with all AML subpopulations. The primary AML subpopulations form two major clusters: L-MPP like and GMP like. LSC subpopulations are indicated in bold. (b) Clustering analysis of TCGA AML samples with normal human HSPC using the 216 DMRs shows that the L-MPP-like and GMP-like clusters are observed in this cohort as well. (c) TCGA samples were classified according to normal HSPC populations based on DNA methylation alone by generating methylation profiles of all the normal HSPC, and then calculating scores of each sample based on the closest population. The normal progenitor cell identity for all the TCGA samples is indicated. (d) The L-MPP-like and GMP-like TCGA samples were grouped according to their FAB classification. NA, not classified.

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