Figure 6: STOML3 modulates Piezo1 channel’s surrounding membrane mechanics via association with cholesterol.
From: Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons

(a) Quantitative comparison of elasticity modulus E1 and E2 values obtained by fitting procedure in HEK293 cells treated with or without MβCD (control: n=16; MβCD: n=17; two-way ANOVA with post hoc Bonferroni’s test, P<0.0001). (b) Quantitative comparison of elasticity modulus E1 and E2 values obtained by fitting procedure in HEK293 cells expressing STOML3 or STOML3-P40 (STOML3: n=25; STOML3-P40: n=23; two-way ANOVA with post hoc Bonferroni’s test, P<0.0001). (c) Quantitative comparison of elasticity modulus E1 and E2 values obtained by fitting procedure in HEK293 cells expressing STOML3 or STOML3-P40 in the presence of Piezo1 channel (Piezo1+STOML3: n=59; Piezo1+STOML3-P40: n=75; two-way ANOVA with post hoc Bonferroni’s test, P<0.0001). *P<0.05, ****P<0.0001. Error bars indicate s.e.m.