Figure 4: Transcriptomics from BAL 3 weeks after immunization. | Nature Communications

Figure 4: Transcriptomics from BAL 3 weeks after immunization.

From: Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis

Figure 4

Total RNA isolated from BAL samples of three animals vaccinated with BCG and another three with MtbΔsigH, obtained 3 weeks after vaccination, was subjected to amplification and macaque-specific DNA microarray analysis. The expression of genes belonging to natural killer cells (a), MAP Kinase (b), JAK/STAT (c), cytokine (d), T cells (e), calcium signalling (f), neuroactive/growth receptors (g) and lipid biosynthesis (h) pathways were induced to significantly higher levels in the BAL of animals vaccinated with MtbΔsigH, relative to those vaccinated with BCG. P values shown are derived from the analysis of significant terms in DAVID with Bonferroni correction for multiple comparisons. BAL samples from three animals in each group were used for microarray experiments.

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