Figure 6: Local T-cell phenotype to immunization in BAL. | Nature Communications

Figure 6: Local T-cell phenotype to immunization in BAL.

From: Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis

Figure 6

Vaccination with MtbΔsigH (dark blue) induced a significantly stronger TH1 cell response relative to BCG vaccination (light blue), or no vaccination (red). Quantification of and representative histograms of CD4+CD69+ (a) and CD8+CD69+ (b) T cells migrating to the lung after vaccination. Absolute cell counts of phenotypic markers CXCR3, CCR5 and CXCR4 in CD4+ (c) and CD8+ (d) T cells in BAL at different stages of infection. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001 using two-way ANOVA with Tukey’s correction for multiple comparisons. Data are means±s.d. BAL samples from all 21 animals (n=7, three groups) were included in the flow cytometry experiments and analyses. Samples from all seven animals in each group were used for analysis at each time point.

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