Figure 3: Permutation analysis of the TCGA acute myeloid leukaemia data sets.
From: Systematic analysis of somatic mutations impacting gene expression in 12 tumour types
(a) Left panel shows the empirical distribution functions of P(D), and the right panel shows the empirical distribution functions of P(F) estimated from different permuted data sets. (b) Heatmap shows the expression of genes connected to RUNX1: red represents high expression and blue represents low expression. Here columns represent patients and rows represent genes. For the patients without RUNX1 mutations, we ‘assume’ the mutations still exist and estimate the probabilities of individual mutations P(F). The mutation type ‘complex’ of a gene in a patient represents the gene harbouring multiple types of mutations in the patient.
