Figure 5: NFE2L2 mutations and FECH upregulation.
From: Systematic analysis of somatic mutations impacting gene expression in 12 tumour types
NFE2L2 mutations were predicted to correlate with FECH expression upregulation in five types of cancer: BLCA, HNSC, LUAD, LUSC and UCEC. Each dot in the scatterplots represents the expression of NFE2L2 and FECH in a patient. A blue cross ‘ × ’ means the patient does not have NFE2L2 mutations. Other types of symbols represent different kinds of mutations (Hlamp, copy number amplifications). The filled colours encode the estimated mutation probability P(F) from trans-analysis (both FECH expression and the expression of other NFE2L2 interaction partners determine P(F)). HNSC, head and neck squamous cell carcinoma; LUAD, lung adenocarcinoma.
