Figure 3: Time course of anticipatory responses in MTL cells (N=42).
From: Learning of anticipatory responses in single neurons of the human medial temporal lobe
(a) Comparison of firing rate during the ISI periods (that is, −500 to 0 ms before stimulus onset) before the preferred and preceding stimuli during AL. Sixty-nine per cent of MTL cells (white circles) showed higher firing rates in the ISI before preferred stimuli (paired t-test, P<0.05). The grey circles correspond to the remaining cells. (b) The strength of the predictive activity calculated with a running average of 15 trials, where on each trial n we considered the difference between the preferred and preceding ISIs based on a moving average of trials n−7 to n+7. The solid black horizontal lines indicate which trials showed a significant learning effect, as computed by a non-parametric bootstrap procedure over 100,000 iterations. The black arrow indicates the eleventh trial, on which the difference between the preferred and preceding ISIs was first significant (P<0.05, non-parametric bootstrap procedure). See also Supplementary Fig. 8.
