Figure 2: Age-associated genes are enriched for the presence of potentially functional methylation sites.
From: The transcriptional landscape of age in human peripheral blood
(a) Quantile–quantile (QQ) plot of the observed P-values (−log10P) for the methylation–age associations. The plot in black shows pvalues from the 1,497 significant age-associated genes, whereas the plot in red shows pvalues for 1,497 random genes. We do not see enrichment for the 1,497 age-associated genes. (b) QQ plot of the observed P-values (−log10P) for the expression–methylation associations. The plot in black shows P values from the 1,497 significant age-associated genes, whereas the plot in blue shows pvalues for 1,497 random genes. The age-associated genes are enriched for CpG methylation sites that associate with gene expression levels.
