Table 1 Top 50 age-associated genes.

From: The transcriptional landscape of age in human peripheral blood

		Discovery		Replication		Meta-analysis			Generalization
Gene	Rank	Z -score	P -value	Z -score	P -value	Number of samples	Z -score	P -value	Cerebellum	Frontal Cortex
CD248	1	−32.48	2.32E−231	−40.13	4.07E−352	15,266	−51.46	1.62E−577	NA	NA
LRRN3	2	−29.12	2.03E−186	−33.55	7.81E−247	15,266	−44.38	3.53E−430	N	Y (−)
NELL2	3	−23.65	1.18E−123	−23.48	6.93E−122	15,266	−33.31	2.67E−243	N	Y (−)
LEF1	4	−22.18	5.57E−109	−22.46	9.38E−112	15,266	−31.56	1.22E−218	NA	NA
CCR7	5	−21.14	3.59E−99	−22.44	1.48E−111	15,266	−30.83	1.04E−208	NA	NA
ABLIM1	6	−22.32	2.34E−110	−20.73	1.71E−95	15,266	−30.41	4.41E−203	N	Y (+)
GZMH	7	18.68	7.03E−78	20.97	1.26E−97	15,266	28.07	2.39E−173	NA	NA
MYC	8	−18.96	3.36E−80	−19.51	9.94E−85	15,266	−27.20	5.96E−163	NA	NA
CD27	9	−17.65	1.07E−69	−20.68	5.13E−95	15,266	−27.15	2.76E−162	NA	NA
FAM102A	10	−19.46	2.24E−84	−18.68	7.11E−78	15,266	−26.95	5.68E−160	N	Y (+)*
SERPINE2	11	−16.08	3.71E−58	−20.95	1.91E−97	14,385	−26.34	7.66E−153	Y (−)	Y (−)**
SLC16A10	12	−20.39	2.29E−92	−16.51	3.15E−61	13,809	−26.15	1.00E−150	Y (+)	Y (−)
FCGBP	13	−15.76	5.50E−56	−20.83	2.49E−96	15,266	−25.95	1.65E−148	NA	Y (+)*
GPR56	14	17.52	9.47E−69	19.02	1.21E−80	15,266	25.86	2.03E−147	NA	NA
BACH2	15	−17.82	4.64E−71	−17.75	1.85E−70	15,266	−25.14	1.71E−139	N	NA
SYT11	16	17.23	1.72E−66	18.23	3.24E−74	15,266	25.08	8.82E−139	Y (−)	Y (−)
PDE9A	17	−17.21	2.22E−66	−18.20	5.44E−74	15,266	−25.05	1.91E−138	N	N
NG	18	−17.01	7.41E−65	−17.52	9.87E−69	15,266	−24.42	1.16E−131	NA	NA
FLNB	19	−15.78	4.26E−56	−18.61	2.87E−77	15,266	−24.36	4.94E−131	N	Y (+)**
NT5E	20	−17.45	3.29E−68	−16.59	8.23E−62	15,039	−24.06	6.98E−128	NA	NA
FGFBP2	21	17.45	3.51E−68	15.79	3.51E−56	15,266	23.47	8.43E−122	NA	NA
TGFBR3	22	15.00	7.73E−51	17.66	9.15E−70	15,266	23.13	2.41E−118	N	Y (+)*
ITM2C	23	−14.41	4.24E−47	−17.73	2.45E−70	15,266	−22.78	7.22E−115	N	N
ATF7IP2	24	−15.52	2.73E−54	−16.61	5.85E−62	15,266	−22.73	2.34E−114	NA	Y (−)*
CR2	25	−16.29	1.10E−59	−15.85	1.51E−56	15,266	−22.71	3.49E−114	NA	NA
FAIM3	26	−17.92	8.65E−72	−14.22	7.40E−46	15,266	−22.65	1.41E−113	NA	NA
PHGDH	27	−13.25	4.56E−40	−18.30	8.10E−75	15,266	−22.39	4.85E−111	N	Y (+)*
LDHB	28	−15.63	4.33E−55	−15.96	2.42E−57	15,266	−22.34	1.55E−110	Y (−)*	Y (−)**
SIRPG	29	−15.64	4.16E−55	−15.45	7.71E−54	15,266	−21.97	5.58E−107	NA	NA
FCRL6	30	13.29	2.83E−40	17.65	9.90E−70	15,266	21.95	9.70E−107	NA	NA
PDE7A	31	−15.58	9.40E−55	−15.37	2.68E−53	15,266	−21.88	4.42E−106	NA	NA
NSIP	32	−14.44	3.12E−47	−16.19	5.74E−59	15,266	−21.68	3.13E−104	N	N
PAICS	33	−16.00	1.26E−57	−14.34	1.29E−46	15,266	−21.42	9.39E−102	N	Y (+)**
BZW2	34	−14.93	2.19E−50	−15.18	4.55E−52	15,266	−21.29	1.42E−100	Y (−)**	Y (−)**
OXNAD1	35	−15.59	9.09E−55	−14.32	1.71E−46	15,266	−21.12	5.66E−99	NA	NA
CX3CR1	36	14.09	4.14E−45	15.66	3.04E−55	14,385	21.07	1.67E−98	NA	NA
SCML1	37	−14.00	1.58E−44	−15.69	1.92E−55	15,266	−21.01	5.02E−98	NA	NA
RPL22	38	−14.91	3.03E−50	−14.79	1.79E−49	15,266	−20.99	8.61E−98	N	Y (−)**
LDLRAP1	39	−14.57	4.19E−48	−14.82	1.15E−49	15,266	−20.78	6.69E−96	N	NA
RHOC	40	12.89	4.89E−38	15.93	3.71E−57	15,266	20.43	8.94E−93	N	Y (+)
LTB	41	−14.90	3.55E−50	−14.02	1.11E−44	15,266	−20.43	9.52E−93	NA	NA
FAM134B	42	−15.17	5.88E−52	−13.43	3.96E−41	15,266	−20.19	1.31E−90	N	N
LBH	43	−14.18	1.29E−45	−14.22	7.04E−46	15,266	−20.07	1.28E−89	NA	Y (−)**
PRSS23	44	14.07	5.76E−45	14.07	6.25E−45	15,266	19.89	5.11E−88	NA	NA
SUSD3	45	−14.26	4.01E−46	−13.91	5.30E−44	14,385	−19.87	6.90E−88	NA	NA
PIK3IP1	46	−14.93	2.02E−50	−13.13	2.16E−39	15,266	−19.81	2.58E−87	Y (+)*	Y (+)**
MFGE8	47	−12.46	1.23E−35	−15.34	4.09E−53	15,266	−19.70	2.06E−86	N	N
AGMAT	48	−13.77	4.14E−43	−14.09	4.34E−45	15,266	−19.70	2.31E−86	NA	NA
NKG7	49	14.43	3.17E−47	13.42	4.53E−41	15,266	19.67	3.67E−86	NA	NA
PPP2R2B	50	13.49	1.81E−41	14.26	4.19E−46	15,266	19.63	9.40E−86	Y (−)*	Y (−)

NA, not expressed.
For the 50 most significant age-associated genes, the discovery P-value (and Z-score), the replication P-value (and Z-score), and the meta-analysis P-value (and sample size and Z-score) are shown. The last two columns display whether the genes were also significantly associated with age in the brain tissues cerebellum and frontal cortex.
Y=P<0.05; Y*=P<0.01; Y**=P<0.0001; N=P≥0.05; (−) or (+) gives the direction of the effect with age.

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Table 1 Top 50 age-associated genes.

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